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Abstract #1636

Altered Spontaneous Brain Activity in Children with type 1 Gaucher disease: a Resting-state fMRI Study

Di Hu1, Shengpei Wang2, Huiying Kang1, Xiaolu Tang1, Hong Zhang1, Huiguang He2, and Yun Peng1

1Beijing children's hospital, Beijing, People's Republic of China, 2Research Center for Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China

This is the first study to examine differences in spontaneous neural activity between GD patients and healthy controls. Our results indicate that decreased of neural activity in motor area; increased neural activity in the olfaction-, vision- and algesthesia -related structures; dysfunction of neural activity in emotion- , recognition- and speech- related structures and cerebellum. These results promote a further understanding of underlying neurophysiological mechanisms in the intrinsic brain of GD type I, which will aid in the development of treatment plans for GD type I patients that address both physical and psychological concern and preventing neurological disease in early stage.

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