Measurements of deoxygenated blood volume (DBV) via the streamlined-qBOLD technique are larger than typically reported in the literature, resulting in underestimation of oxygen extraction fraction (OEF). In this study we address this limitation by acquiring a separate measurement of DBV using the BOLD response to the administration of oxygen, which has been shown to be specifically sensitive to venous blood volume. By combining measurements of the reversible transverse relaxation rate, R2′, and DBV to measure OEF, we were able to show better agreement with whole brain OEF from the TRUST method than OEF measured with streamlined-qBOLD.
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