Measurements of cerebral venous O2 saturation with MRI would enable use to estimate brain O2 consumption, a marker of brain activity. Here we propose a new method with this aim, that exploits a Fourier velocity encoding scheme combined with multi-echo acquisitions for estimating 𝑇2* and then, through calibration curves, O2 saturation. Synthetic data are analysed and pilot data from resting state and visual stimulus acquisitions (two subjects) are reported. The new method is shown to supply plausible estimates of baseline levels and changes in O2 saturation in the sagittal sinus following stimulation.
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