The BOLD signal in functional connectivity MRI(fcMRI) may be affected by non-neural factors, such as vascular function. In this study, we utilized a multiparametric mapping method to measure functional connectivity(FC) maps and cerebrovascular reactivity(CVR) concomitantly, and examined the relationship between these two indices in both healthy volunteers and patients with cerebrovascular disease. Significant correlations were found between FC and CVR across brain regions, suggesting that cerebrovascular function should be accounted for when using BOLD fcMRI to assess brain functions. Concomitant acquisition of neural and vascular MRI may allow calibration/normalization of FC signal and more accurate estimation of brain functional connectivity.
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