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Abstract #1665

Towards self-calibrated functional connectivity mapping

Peiying Liu1, Marco Pinho2, Yang Li1, Li Pan3, Babu G Welch2,4, and Hanzhang Lu1

1Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Siemens Healthcare, Baltimore, MD, United States, 4Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States

The BOLD signal in functional connectivity MRI(fcMRI) may be affected by non-neural factors, such as vascular function. In this study, we utilized a multiparametric mapping method to measure functional connectivity(FC) maps and cerebrovascular reactivity(CVR) concomitantly, and examined the relationship between these two indices in both healthy volunteers and patients with cerebrovascular disease. Significant correlations were found between FC and CVR across brain regions, suggesting that cerebrovascular function should be accounted for when using BOLD fcMRI to assess brain functions. Concomitant acquisition of neural and vascular MRI may allow calibration/normalization of FC signal and more accurate estimation of brain functional connectivity.

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