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Abstract #1666

Clinical mapping of cerebrovascular reactivity using MRI: a framework for reaching consensus

Molly G Bright1, Erin L Mazerolle2, Olivia Sobczyk3, Audrey P Fan4, Matthias JP van Osch5, Clarisse I Mark6, Laurentius Huber7, Avery JL Berman2,8, Daniel P Bulte9, Bruce G Pike2, Claudine J Gauthier10, and Nicholas P Blockley11

1Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 2Hotchkiss Brain Institute, Department of Radiology, University of Calgary, Canada, 3Institute of Medical Science, University of Toronto, Canada, 4Radiological Sciences Laboratory, Stanford University, United States, 5C.J. Gorter Center for High Field MRI, Radiology, Leiden University Medical Center, Netherlands, 6Centre for Neuroscience Studies, Queen’s University, Canada, 7Section on Funtional Imaging Methods, National Institute for Mental Health, United States, 8Montreal Neurological Institute, McGill University, Canada, 9Institute of Biomedical Engineering, University of Oxford, United Kingdom, 10PERFORM Centre, Concordia University, Canada, 11FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom

There is increasing clinical interest in mapping cerebrovascular reactivity (CVR), the response of cerebral blood vessels to a carbon dioxide stimulus. However, the application of CVR mapping varies greatly across sites due to a lack of methodological standardisation. We established an international network of over 100 researchers and administered a survey to establish current practice. Guided by QIBA and UPICT protocols, we developed a framework for reaching consensus, and identified areas where agreement already exists. Immediate achievable targets and long-term aims for the CVR community are defined, with the ultimate goal of establishing CVR as a robust clinical imaging marker.

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