Abstract #1673

Non-invasive evaluation of functional and structural connectome changes in the mouse brain related to drug-induced neuro-modulation

Thomas Bienert¹, Neele Hübner¹, Anna Mechling¹, Tanzil Mahmud Arefin^1,2,3, Marco Reisert⁴, Máté Döbrössy⁵, Philipp Janz⁶, Carola Haas⁶, Laura Adela Harsan^1,7,8, Jürgen Hennig⁴, Dominik von Elverfeldt¹, and Karl Egger⁹

¹Advanced Molecular Imaging Research (AMIR), Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, ²Faculty of Biology, University of Freiburg, Freiburg, Germany, ³Department of Translational Medicine and Neurogenetics, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, Strasbourg, France, ⁴Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, ⁵Division of Stereotactic and Functional Neurosurgery, Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany, ⁶Experimental Epilepsy Research, Department of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany, ⁷Department of Biophysics and Nuclear Medicine, University Hospital Strasbourg, Strasbourg, France, ⁸Laboratory of Engineering, Informatics and Imaging, University of Strasbourg, Strasbourg, France, ⁹Department of Neuroradiology, University Medical Center Freiburg, Freiburg, Germany

Analysis of neuro-functional connectivity derived from rs-fMRI and neuro-structural connectivity derived from DTI/Fiber Tracking might enable researchers to monitor and characterize physiological or drug induced neuro-modulation in the mouse brain. In our study we present a framework for the analysis on healthy mice with erythropoietin (EPO) treatment. Brain regions with pronounced neuro-modulation in histology also showed changes in neuro-functional and neuro-structural data.

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