Isoflurane is widely used in biomedical research
with the prolonged duration of administration up to several hours. However, the
manner in which neurophysiology and functional connectivity are affected by the
length of anesthesia remains poorly understood. In the present study, cerebral
blood flow (CBF) and default model network (DMN) were examined using arterial
spin-labeling perfusion and resting state functional MRI techniques. The functional connectivity in the
dominant DMN decreased substantially during 4-hour administration of isoflurane
at any given dosage. CBF in most brain
regions decreased at the low dose (0.89 %), but did not change markedly when higher doses of isoflurane (1.05 %,
1.19 %) were administrated. The study revealed dose-dependent effects of
isoflurane on brain functionality and regional CBF during prolonged anesthesia
administration of isoflurane, suggesting those effects should be considered in
the experimental design or the interpretation of the outcome of related
neuroimaging studies using anesthetized animals or humans.
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