Abstract #1678

Differential effects of anesthetics on mouse brain connectivity and function as probed by resting-state fMRI and [18]FDG-PET

Meltem Karatas^1,2,3,4, Laetitia Degiorgis¹, Marion Sourty¹, Daniel Roquet¹, Lionel Thomas⁵, Patrice Marchand⁵, Thomas Bienert³, Lee Hsu-Lei³, Julien Lamy¹, Chrystelle Po¹, Frédéric Boisson⁵, David Brasse⁵, Dominik von Elverfeldt³, Izzie Jacques Namer^1,6, Jean-Paul Armspach¹, Ipek Yalcin², and Laura-Adela Harsan^1,3,6,7

¹ICube, CNRS, University of Strasbourg, Strasbourg, France, ²INCI, CNRS, University of Strasbourg, Strasbourg, France, ³Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany, ⁴Faculty of Biology, University of Freiburg, Freiburg, Germany, ⁵IPHC, CNRS, University of Strasbourg, Strasbourg, France, ⁶Engineering Science, Computer Science, and Imaging Laboratory, Integrative Multimodal Imaging in Healthcare, CNRS, University of Strasbourg, Strasbourg, France, Strasbourg, France, ⁷Department of Biophysics and Nuclear Medicine, University Hospital Strasbourg, Strasbourg, France

Mice resting state functional connectivity (FC) studies are highly attractive given the large number of existing murine models of neuropsychiatric disorders. Currently, most of mouse rs-fMRI studies are carried out under anesthesia, to limit motion and animal distress. Yet, anesthetics affect brain FC. Currently, no reliable awake mouse brain FC reference is available. We compared mouse brain rs-fMRI patterns under medetomidine or isoflurane anesthesia and paralleled the experiments with static ¹⁸FDG-PET exams, where the tracer biodistributions occurred under isoflurane, medetomidine anesthesia or in conscious state, reflecting the brain glucose metabolism, as indirect measures of neuronal activity.

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