In clinical practice, for complex, recurrent disease, the same patient may need to use contrast agents repeatedly. However, the administration of multiple use of contrast-medium within a short period of time may put patients at risk1 .So, the aim of this work is to examine differences in rats’ potential kidney injury provoked by iodixanol with respect to different intervals and different times. By using fMRI we observed whether repeated intravenous injection of iodixanol at different time intervals could lead to aggravate kidney damage and then find the shortest time interval. Simultaneously, monitoring kidney damage by sNGAL and detecting the cause of renal injury by immunohistochemistry were also performed.
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