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Abstract #1681

Tradeoffs in pushing the spatial resolution of fMRI for the 7 T Human Connectome Project

An Thanh Vu1, Keith Jamison2, Matthew F Glasser3, Steve M Smith4, Timothy Coalson3, Steen Moeller2, Edward J Auerbach2, Kamil Ugurbil2, and Essa Yacoub2

1Center for Imaging of Neurodegenerative Diseases, Veteran Affairs Health Care System, San Francisco, CA, United States, 2Center for Magnetic Resonance Imaging, University of Minnesota, 3Washington University, 4Oxford Centre for Functional MRI of the Brain, Oxford University

Here we describe subsequent work by the Human Connectome Project (HCP), taking the initial advancements obtained at 3 T and pushing spatial resolution even further at ultrahigh field strengths. To assess the impact of spatial resolution on the resultant detectability of resting state networks throughout the brain, we compare 7 T data acquired at various isotropic spatial resolutions (2 mm, 1.6 mm, 1.5 mm, 1.25 mm, and 0.9 mm) using the 2 mm 3 T HCP rfMRI data as baseline. 7 T functional networks show enhanced BOLD CNR, resulting in sharper, stronger, and more well defined spatial detail even at the group level.

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