Abstract #1700

Localization of the epileptogenic neural network by the resting state fMRI in patients with the temporal lobe epilepsy

Oleksii Omelchenko¹, Mykola Makarchuk¹, and Volodymyr Rogozhyn²

¹Human and Animal Physiology, Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, ²Radiology Department, Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine

Precise localization of the epileptogenic zone and its delineation from eloquent cortex, are crucial for successful surgery. We propose analysis of macroscopic brain neural networks connectivity in the resting state and during the movement execution in patients with TLE for the possible epileptogenic macroscopic neural network localisation and motor cortex mapping. Our results show the concordant topography of the resting state network and the EEG epileptiform activity. Resting state fMRI could potentially depict the epileptogenic neural network in TLE which includes regions of temporal lobe and hippocampus. Motor network was shown to remain unaffected in TLE during interictal period.

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