Abstract #1701

Higher Thalamocortical Connectivity May Reduce Efficacy of Temporal Resection

Bryson B Reynolds¹, Jasmine S Sondhi¹, Monica Giraldo-Chica², Baxter P Rogers¹, Bennett A Landman³, Bassel Abou-Khalil⁴, Adam W Anderson⁵, and Victoria L Morgan¹

¹Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ²Psychiatry, Vanderbilt University Medical Center, Nashville, TN, United States, ³Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, ⁴Neurology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

Functional connectivity of the thalamus could inform the potential efficacy of temporal resection in temporal lobe epilepsy. Diffusion and functional MRI was collected from 22 patients who underwent surgical treatment for temporal lobe epilepsy. The thalamus was segmented into six subregions based on diffusion tractography to six regions encompassing the entire cortex. Functional connectivity was calculated between each thalamic subregion and cortical region for each patient. Higher functional connectivity between the contralateral temporal-thalamic subregion and the cortex was associated with seizure recurrence after surgery.

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