Abstract #1703

Patterns of the whole brain default mode network for alcohol addiction among the alcohol preferring rats

Yue Liu¹, Ning Zheng², Taotao Liu³, Binbin Nie⁴, Jie Wang², and Fuqiang Xu²

¹Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, People's Republic of China, ²Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuan, People's Republic of China, ³Department of Anesthesiology, Peking University Third Hospital, Beijing, People's Republic of China, ⁴Insititute of High Energy Physics, Chinese Academy of Sciences, Beijing, People's Republic of China

Alcohol preferring and non-preferring rats were trained with two-bottle choice methods. The whole brain default mode network was acquired during different period of addiction training and after alcohol injection. The correlation coefficients among 28 regions were calculated by mean-value of Pearson correlation. The changes of brain connections after alcohol consumption in different stage of alcohol addiction is significant different. Furthermore, some addiction or reward associated regions and new possible areas (NAc, Tu, VTA, IC, Hypo, SNC, Au, DB, Hipp, VLPO, etc.) showed difference during the training. Our findings could provide preliminary functional connection support of neurobiological circuits change.

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