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Abstract #1704

Cocaine applied in a “binge paradigm” induces a region-specific and persistent brain circuitry modulation.

Elisabeth Jonckers1, Michael Belloy1, Dany Dsouza2, Marleen Verhoye1, Thomas Mueggler2, and Annemie Van der Linden1

1Bio-Imaging Lab, University of Antwerp, Wilrijk, Belgium, 2Roche Pharma Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland

Our pre-clinical rodent study showed an increased Functional Connectivity at the level of the striatum and the cingulate cortex induced by cocaine injection. The effect was detectable 4 hours after administering cocaine and sustained for 24h.

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