Abstract #1705

Resting state fMRI in Patients Infected with Hepatitis C Virus

Santosh Kumar Yadav¹, Ajay Vardaan², Rakesh Kumar Gupta³, Pradeep Kumar Gupta³, Samir Mohindra⁴, Deepak Kaura⁵, Francesco Marincola¹, Ena Wang¹, and Mohammad Haris¹

¹Research Department, Sidra Medical and Research Center, Doha, Qatar, ²Department of Medicine, King George Medical University, Lucknow, India, ³Department of Radiology and Imaging, Fortis Memorial Research Institute, India, ⁴Department of Gastroenterology, Sanjay Gandhi Post graduate Institute of Medical Science, India, ⁵Department of Radiology, Sidra Medical and Research Center, Doha, Qatar

Current study measured the amplitude of low-frequency fluctuations (ALFF) and insular functional connectivity (FC) in Hepatitis C virus patients and compared with age and gender matched control using RESTplus software. HCV patients showed significantly reduced ALFF in the right insula. The right insular FC strength was lower in patients than control. Neuropsychological test scores were significantly lower in HCV patients. Changes in ALFF and FC provide new evidences of altered neuronal activity in HCV patients.

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