Abstract #1706

Resting state fMRI in Migraine

Kenneth M Jackson¹, Steven C Liu¹, Maryam Falahpour¹, Christy Jackson², Frank Haist³, Richard B Buxton¹, and David J Dubowitz¹

¹Radiology, University of California San Diego, La Jolla, CA, United States, ²Neurology, Scripps Clinic, La Jolla, CA, United States, ³Psychiatry, University of California San Diego, La Jolla, CA, United States

We used resting state fMRI to evaluate changes in functional connectivity during migraine episodes, and the response to treatment. The results provide preliminary evidence for a change in functional connectivity in the DMN during migraine, and for the ability of serotonin agonists to restore resting state connectivity. We also identified key brain regions impacted by migraine and then normalized following sumatriptan.

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