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Abstract #1720

Relationship between static and dynamic brain functional connectivity in autism spectrum disorders

Adam Liska1,2, Hongyuan You3, and Payel Das4

1CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy, 2Functional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems @ UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy, 3Department of Computer Science, University of California, Santa Barbara, Santa Barbara, CA, United States, 4IBM Thomas J. Watson Research Center, Yorktown Heights, NY, United States

There is an increased interest in the dynamics of brain functional connectivity, as measured via temporal covariance in resting-state fMRI BOLD signal, and its aberrations in brain disorders. We studied and compared two measures of regional dynamic behaviour, flexibility and variability, across two datasets and show that patients diagnosed with autism spectrum disorder show increased dynamic connectional variability in several brain regions. Furthermore, we establish an interesting association between static and dynamic functional connectivity measures.

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