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Abstract #1724

Interrogating neurotransmitter systems using resting-state fMRI

Joanes Grandjean1, Michaela Bürge2, David Bühlmann3, Hannes Sigrist2, Erich Seifritz2, Franz X. Vollenweider2, Christopher R. Pryce2, and Markus Rudin3,4

1Singapore BioImaging Consortium, Agency for Science, Research and Technology, Singapore, Singapore, 2Psychiatric Hospital, University of Zurich, Switzerland, 3Institue for Biomedical Engineering, University and ETH Zürich, Switzerland, 4Institute of Pharmacology and Toxicology, University of Zurich, Switzerland

We assessed functional connectivity (FC) in the mouse brain following psilocybin administration. Conventional analysis using dual regression and reference spatial maps derived from independent component decomposition identified a decrease in FC within the ventral striatum network in animals administered with psilocybin relative to vehicle. Dopamine D1 and serotonin 5HT2a receptor gene expression as well as projection maps from the ventral tegmental area and dorsal raphe nuclei obtained from the Allen Brain Institute database were used as spatial references in a secondary dual regression analysis to disentangle the contribution of dopamine and serotonin systems to whole-brain functional connectivity changes.

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