The anomalous diffusion behavior of biological tissue has been investigated by several studies using non-Gaussian diffusion models. Among these, the fractional motion (FM) model has attracted an intense interest by the biophysics community and was recently been introduced to the MR community. The current diffusion signal formulism based on the FM model is limited to a simple Stejskal-Tanner gradient despite the widespread use of the eddy-current-resistant gradient waveform with the twice-refocused spin echo (TRSE) technique. In this study, we theoretically derive a formulism based on the FM diffusion model to characterize anomalous diffusion using a TRSE sequence, and experimentally validate it on healthy human brain in vivo.
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