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Abstract #1738

Translocation of Water Molecules in Tissue

Gregory J Wilson1, Charles S Springer2, and Jeffrey H Maki1

1Radiology, University of Washington, Seattle, WA, United States, 2Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, United States

Numerical simulations of water molecule translocation are presented. The molecules execute random walks in a 3D ensemble of digital cells with density and size pertinent for biological tissue. The mean net displacements reflect “hindered” or “restricted” translocations for both extra- and intracellular water, characterized by an infinite number of exponentials. The hindrance is very sensitive to the cell membrane permeability, in the range for tissue – and controlled by active cell metabolism.

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