White matter tract integrity (WMTI) can be used to characterize tissue microstructure in areas with strongly aligned fiber bundles. Several WMTI biomarkers have now been validated against microscopy and provided promising results in studies of brain development, aging, and brain disorders. In clinical settings, however, the diffusion kurtosis imaging (DKI) protocol utilized as part of WMTI imaging may be prohibitively long. Consequently, the diagnostic value of the WMTI parameters is mostly explored in dedicated animal studies and clinical studies of slowly progressing diseases. Here, we evaluate WMTI based on recently introduced axisymmetric DKI which has lower data demand than conventional DKI.
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