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Abstract #1742

White matter biomarkers from fast protocols using axially symmetric diffusion kurtosis imaging

Brian Hansen1, Ahmad Raza Khan1, Noam Shemesh2, Torben Ellegaard Lund1, Ryan Sangill1, Leif Østergaard1, and Sune Nørhøj Jespersen1,3

1CFIN/MINDLab at the Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 2Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, 3Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

White matter tract integrity (WMTI) can be used to characterize tissue microstructure in areas with strongly aligned fiber bundles. Several WMTI biomarkers have now been validated against microscopy and provided promising results in studies of brain development, aging, and brain disorders. In clinical settings, however, the diffusion kurtosis imaging (DKI) protocol utilized as part of WMTI imaging may be prohibitively long. Consequently, the diagnostic value of the WMTI parameters is mostly explored in dedicated animal studies and clinical studies of slowly progressing diseases. Here, we evaluate WMTI based on recently introduced axisymmetric DKI which has lower data demand than conventional DKI.

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