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Abstract #1743

Inferring cell morphology in the heart with a compartment model of diffusion MRI

Darryl McClymont1, Irvin Teh1, Hannah Whittington1, Craig Lygate1, and Jürgen Schneider1

1Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

We propose a three-compartment model to perform cytometry in cardiac diffusion MRI. Our approach adapts the VERDICT model to account for the anisotropic geometry of cardiomyocytes. The model was fit to data from ex-vivo mouse heart imaged with multiple diffusion times, diffusion directions, and q-shells. The model yields realistic volume fractions (intracellular/extracellular/vascular = 68/16/16%) and cell radii (7-9.5 μm). The parameters derived could aid quantitative characterisation of cardiomyopathies including hypertrophy and fibrosis.

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