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Abstract #1745

The Impact of Edema and Crossing Fibers on Diffusion MRI: ODF vs. DBSI

Ze-Zhong Ye1, Sam Gary2, Sourajit Mitra Mustafi3, G. Russell Glenn4,5,6, Fang-Cheng Yeh7, Chunyu Song8, Peng Sun9, Yu-Chien Wu3, Jens H. Jensen4,5, and Sheng-Kwei Song8,9,10

1Chemistry, Washington University, St. Louis, MO, United States, 2Biology, Juniata College, Huntingdon, PA, United States, 3Center for Neuroimaging, Indiana University, Indianapolis, IN, United States, 4Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC, United States, 5Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States, 6Neurosciences, Medical University of South Carolina, Charleston, SC, United States, 7Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, United States, 8Biomedical Engineering, Washington University, St. Louis, MO, United States, 9Radiology, Washington University, St. Louis, MO, United States, 10Hope Center for Neurological Disorder, Washington University, St. Louis, MO, United States

We quantitatively examined the effect of fiber crossing and edema on DTI metrics employing phantoms made of mouse trigeminal nerves and agarose gel. Edema mimicked by gel coating significantly impaired the accuracy of estimated crossing angles using the diffusion orientation distribution function. Diffusion basis spectrum imaging (DBSI) was able to estimate crossing angles in the presence of edema and recover individual nerve baseline diffusivity.

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