In this study, the neurite orientation dispersion and density imaging (NODDI) was used to investigate the spinal cord microstructure for postoperative CSM patients. MRI data were acquired on eleven patients with a long time after surgery. The value of the calculated parameters (OD, Viso and Vic) were preliminarily evaluated. Statistical results show that OD of grey matter is lower at the stenotic level than the normal level, and Viso in both grey and white matter is higher. To the best of our knowledge, this is the first time that the application of NODDI in the spinal cord disease was reported.