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Abstract #1749

Preliminary Investigation on NODDI for Studying Spinal Cord Microstructure of Postoperative CSM Patients

Xiaodong Ma1, Xiao Han2, Wen Jiang3, Zhe Zhang1, Erpeng Dai1, Yishi Wang1, Xiaoguang Cheng3, and Hua Guo1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, Beijing, People's Republic of China, 2Department of Surgery, Beijing Jishuitan Hospital, Beijing, China, Beijing, People's Republic of China, 3Department of Radiology, Beijing Jishuitan Hospital, Beijing, China

In this study, the neurite orientation dispersion and density imaging (NODDI) was used to investigate the spinal cord microstructure for postoperative CSM patients. MRI data were acquired on eleven patients with a long time after surgery. The value of the calculated parameters (OD, Viso and Vic) were preliminarily evaluated. Statistical results show that OD of grey matter is lower at the stenotic level than the normal level, and Viso in both grey and white matter is higher. To the best of our knowledge, this is the first time that the application of NODDI in the spinal cord disease was reported.

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