Abstract #1750

Exploring ex vivo brainstem complex pathways with diffusion microstructure at 11.7T

Sophie Bernadette Sébille^1,2, Anne-Sophie Rolland², Carine Karachi^2,3, Marie-Laure Welter^2,4, Eric Bardinet^1,2, and Mathieu David Santin^1,2

¹Center of NeuroImaging Research - CENIR, Paris, France, ²Inserm U 1127, CNRS UMR 7225, Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France, ³AP-HP, Hôpital de la Pitié-Salpêtrière, Department of Neurosurgery, Paris, France, ⁴AP-HP, Hôpital de la Pitié-Salpêtrière, Department of Neurology, Paris, France

We performed multi-shell 3D segmented EPI on a post mortem macaque brain at 11.7T (resolution 200 μm iso, 120 directions) and evaluated NODDI as a tool to accurately extract brainstem pathways. We showed that the orientation dispersion map can help in segmenting ROIs used for tractography. Microstructure information opens promising perspectives for the exploration of the brainstem complex organization ex vivo in human and non-human primate.

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