Meeting Banner
Abstract #1751

Introducing axonal myelination in connectomics: a preliminary analysis of g-ratio distribution in healthy subjects

Matteo Mancini1,2, Giovanni Giulietti2, Nick Dowell3, Barbara Spanò2, Neil Harrison3, Marco Bozzali2, and Mara Cercignani2,3

1University of Rome "Roma Tre", Rome, Italy, 2Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy, 3Clinical Imaging Sciences Centre, University of Sussex, Brighton, United Kingdom

We estimated the g-ratio (i.e., the ratio of the inner and the outer diameters of myelinated axons) in-vivo in two different datasets of healthy subjects using diffusion and magnetization data. We used this measure to characterize the organization of the structural connectome and compared it to the information obtained by the streamlines reconstructed using tractography. The g-ratio significantly differentiated hub-related aspects of the connections and subcortico-cortical organization. These preliminary results showed that this measure could provide complementary information to the connectome structure.

This abstract and the presentation materials are available to members only; a login is required.

Join Here