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Abstract #1754

Cerebellar connectivity influences brain network topology

Fulvia Palesi1,2, Giovanni Savini2,3, Letizia Casiraghi2,4, Gloria Castellazzi2,5, Paolo Vitali6,7, Giancarlo Germani6,7, Egidio D'Angelo2,4, and Claudia AM Gandini Wheeler-Kingshott4,6,8

1Department of Physics, University of Pavia, Pavia, Italy, 2Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy, 3Department of Physics, University of Milan, Milan, Italy, 4Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, 5Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy, 6Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy, 7Neuroradiology Unit, C. Mondino National Neurological Institute, Pavia, Italy, 8Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom

Graph theory based approaches applied to diffusion weighted MRI data have been used for understanding cerebral processing at whole-brain scale. Nevertheless, a few studies have considered including the connectivity with the cerebellum. In this work, the cerebellar role in the whole-brain connectomic was investigated by combining automatic tools and a priori information about cerebellar connections. We assert that it is important to incorporate the knowledge that cerebro-cerebellar connections are all contralateral. Moreover, our findings demonstrate that network topology is highly influenced by the presence or the absence of the cerebellum suggesting that it plays a key role in brain processing.

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