Abstract #1755

Comparison of between-subject and single-subject between-session variability in in vivo DKI brain studies

Nino Kobala¹, Farida Grinberg^1,2, Ezequiel Farrher¹, Ketevan Kotetishvili³, and Jon N Shah^1,2

¹Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine - 4, Juelich, Germany, ²JARA, RWTH Aachen University, Department of Neurology, Faculty of Medicine, Aachen, Germany, ³Georgian Technical University, Department of Physics, Tbilisi, Georgia

The knowledge of intra- and inter-subject variability of diffusion kurtosis imaging metrics plays an important role for interpretation of the results of the clinical trials. The purpose of this work is to investigate and compare between-session variability of a single subject with between-subject variability diffusion kurtosis parameters in different anatomical regions. Variability is quantified in terms of the coefficient of variation, which can provide the baseline for interpretation of clinical trials and single-subject longitudinal examinations.

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