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Abstract #1756

MR imaging of the cervical spinal cord in patients with spinal muscular atrophy and healthy controls

Wieke Haakma1,2, Marloes Stam3, Martijn Froeling1, Marielle E.P. Philippens4, Clemens Bos1, Alexander Leemans5, Ludo van der Pol3, and Jeroen Hendrikse1

1Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Department of Forensic Medicine and Comparative Medicine Lab, Aarhus University, Aarhus, Denmark, 3Department of Neurology, University Medical Center Utrecht, Utrecht, Netherlands, 4Department of Radiotherapy, Cancer Center, University Medical Center Utrecht, Utrecht, Netherlands, 5Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

We studied the architecture and diffusion characteristics in the cervical spine and nerves in spinal muscular atrophic (SMA) patients and healthy controls. We showed the asymmetrical architectural configuration of the cervical nerves in SMA patients. We computed diffusion values of which the mean, axial, and radial diffusivity were lower in the SMA patients than in healthy controls which are in accordance with the clinical symptoms of these patients. Diffusion values of the cervical spine (grey, white and the whole myelum) showed no differences.

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