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Abstract #1765

Can we trust structural connectivity?

Silvia Obertino1, Flora Danti1, Mauro Zucchelli1, Francesca Benedetta Pizzini2, and Gloria Menegaz1

1Computer Science, University of Verona, Verona, Italy, 2Neuroradiology, University Hospital Verona, Verona, Italy

Structural connectivity models result from a complex processing chain involving many different steps, each having an impact on the reliability of the final measures. One of the hottest questions in the state-of-the-art is thus “To which extent can we trust the structural connectome?”. In this work, we tackled this issue by focusing on the typical processing pipeline and investigating the impact of the main involved steps. MRTrix CSD-based probabilistic tractography provided the highest stability across subjects and MRTrix reached the largest distance with respect to other softwares in both individual subject and group analysis.

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