Abstract #1764

Can fast diffusion kurtosis imaging be quantitative in the brain?

Yen-Shu Kuo^1,2, Shun-Chung Yang³, Ya-Fang Chen³, and Wen-Chau Wu^3,4,5

¹Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ²Radiology, Cathay General Hospital, Taipei, Taiwan, ³Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, ⁴Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, ⁵Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, Taiwan

This study was aimed to investigate the applicability of fast DK imaging for both cerebral gray matter and white matter as a quantitative method. Our experimental data reveal that the dependence of D and K on b-values predominantly exists in areas containing a noticeable amount of cerebrospinal fluid. D is more sensitive to b-value choice than K. With b-values carefully chosen to account for signal-to-noise ratio and model fidelity, fast DK imaging-derived indexes can be quantitative with negligible dependence on b-values in most gray matter and white matter.

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