Diffusion tensor imaging is an established tool for the examination of WM connectivity and microstructural changes across the lifespan. More recently, advanced diffusion MRI techniques, such as diffusion kurtosis imaging (DKI), have been shown to provide richer information on tissue microstructure. Thus far, only a few works have been published related to DKI in healthy ageing. In this work, we examined, in a large cohort of subjects, the potential of DKI metrics to unravel microstructural changes due to ageing in different brain regions.
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