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Abstract #1769

Diffusion kurtosis metrics as sensitive biomarkers of ageing

Farida Grinberg1,2, Nino Kobalia1, Ezequiel Farrher1, and N. Jon Shah1,2,3

1Institute of Neuroscience and Medicine 4, Research Centre Jülich, Jülich, Germany, 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 3JARA - BRAIN - Translational Medicine, RWTH Aachen University, Germany

Diffusion tensor imaging is an established tool for the examination of WM connectivity and microstructural changes across the lifespan. More recently, advanced diffusion MRI techniques, such as diffusion kurtosis imaging (DKI), have been shown to provide richer information on tissue microstructure. Thus far, only a few works have been published related to DKI in healthy ageing. In this work, we examined, in a large cohort of subjects, the potential of DKI metrics to unravel microstructural changes due to ageing in different brain regions.

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