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Abstract #1770

Stability of co-electrospun brain-mimicking fibers for diffusion MRI

Fenglei Zhou1,2, Matthew Grech-Sollars3, Adam Waldman3,4, Geoffrey J. M. Parker1,5, and Penny L. Hubbard Cristinacce6

1Division of Informatics, Imaging & Data Sciences, School of Health Sciences, The University of Manchester, Manchester, United Kingdom, 2The School of Materials, The University of Manchester, Manchester, United Kingdom, 3Division of Brain Sciences, Imperial College London, London, United Kingdom, 4Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom, 5Bioxydyn Limited, Manchester, United Kingdom, 6Division of Neuroscience & Experimental Psychology, The University of Manchester, United Kingdom

This work investigates the stability and reproducibility of brain-mimicking microfiber phantoms. These microfibers were produced by co-electrospinning (co-ES) and characterized by scanning electron microscopy (SEM). Grey matter (GM) and white matter (WM) phantoms were constructed from random and aligned microfibers, respectively. MR data were acquired from these phantoms over a period of 17 months. SEM images reveal that there were some changes in the pore size and porosity of co-ES fibers over a period of 30 months. MR measurements showed variations within the limits expected for intra-scanner variability, thereby confirming the phantom stability over 17 months.

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