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Abstract #1771

Abnormal white matter integrity in parkinson’s disease patients with cognitive impairment revealed by tract-based spatial statistics

Hui Yu1 and Mingming Huang1

1Department of Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang, China, Guiyang, People's Republic of China

Results from recent neuroimaging studies suggest that PD patients with cognitive impairment(PDCI) is associated with abnormal white matter integrity. In this study, we used tract-based spatial statistics (TBSS) method combined with diffusion tensor imaging (DTI) to investigate the microstructural integrity of the white matter in PDCI. Results from TBSS demonstrated that PDCI patients had significantly lower FA than healthy controls in anterior thalamic radiation(atr), corticospinal tract (cst), cingulated gyrus(cg), forceps minor(fi), the right inferior fronto-occipital fasciculus(ifo), inferior longitudinal fasciculus(ilf), superior longitudinal fasciculus(slf) and uncinate fasciculus(uf). There were no white matter integrity changes in PD patients without cognitive dysfunction, And also significantly correlation was found between FA in the right ifo and MoCA scores.

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