Abstract #1772

Changes of non-Gaussian diffusion MRI parameters at different diffusion times in a human breast carcinoma xenograft model

Mami Iima^1,2, Tomomi Nobashi³, Hirohiko Imai⁴, Sho Koyasu⁵, Akira Yamamoto¹, Masako Kataoka¹, Yuji Nakamoto¹, Tetsuya Matsuda⁶, and Kaori Togashi¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Hakubi Center for Advaned Research, Kyoto University, Kyoto, Japan, ³Graduate Schoolof Medicine, Kyoto University, Kyoto, Japan, ⁴Research and Educational Unit of Leaders for Integrated Medical System, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Kyoto, Japan, ⁵Radiation Biology Center, Kyoto University, Kyoto, Japan, ⁶Department of Systems Sciece, Graduate School of Informatics, Kyoto University, Kyoto, Japan

The relationship between diffusion time and diffusion parameters obtained from 7.0T MRI using a human breast carcinoma xenograft model was investigated. There was an increase in K values and decrease in ADCo as well as sADC values in 27.6ms compared to 9.6 ms. Some tumor showed heterogeneous sADC change derived from two different diffusion times.

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