Abstract #1774

Clinically Feasible Optic Nerve Diffusion Basis Spectrum Imaging at 3T

Joo-won Kim^1,2,3, Peng Sun⁴, Sheng-Kwei Song⁴, Samantha Lancia⁵, Courtney Dula⁵, Robert T Naismith⁵, and Junqian Xu^1,2,3,6

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Radiology, Washington University, Saint Louis, MO, United States, ⁵Department of Neurology, Washington University, Saint Louis, MO, United States, ⁶Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, United States

Optic nerve MRI is susceptible to eyeball movement. The relatively long acquisition time of advanced diffusion MRI (dMRI) methods exacerbates the motion sensitivity in optic nerve dMRI and limits the clinical implementation of these methods. In this work, we evaluate a short (less than 2.5 min per eye) single slice coronal optic nerve dMRI acquisition protocol at 3T and propose a 2D optic nerve center searching algorithm customized for such dMRI data. We demonstrate improved optic nerve center contrast after image alignment and the expected benefits of reduced partial volume effects from diffusion basis spectrum imaging (DBSI) analysis.

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