We evaluated the utility of compressed sensing (CS) for diffusion tensor (connectomic) histology in the mouse brain at high field (9.4T). We explored the effect of b values, compression factors, and k-space sampling strategies. We were able to achieve compression factors of 4X through judicious choice of k-space sampling patterns. Comparison to a comprehensively acquired data set (full sampling at 43 μm with 120 angles) allowed us to reduce the acquisition time by nearly 30X with minimal loss in the resulting connectome.
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