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Abstract #1779

Prediction of outcome in bilateral common carotid artery occlusion (BCCAO) rats by intravoxel incoherent motion (IVIM) analysis at 11.7 Tesla

Shunrou Fujiwara1,2, Yuki Mori2,3, Daniela Martinez de la Mora2,3, Kuniaki Ogasawara1, and Yoshichika Yoshioka2,3

1Department of Neurosurgery, Iwate Medical University, Morioka, Japan, 2WPI Immunology Frontier Research Center, Osaka University, Suita, Japan, 3Center for Information and Neural Networks (CiNet), NICT and Osaka University, Suita, Japan

Rats with the bilateral carotid artery occlusion (BCCAO) was often used for assessment of the brain damage caused by chronic cerebral hypoperfusion as a longitudinal ischemic animal model; however, the mortality is high and it has remained unclear what kinds of initial cerebral hemodynamic changes occurred in the brain in the hyperacute phase after BCCAO and whether the changes related with the mortality in rats or not. Intravoxel incoherent motion (IVIM), which is the basic concept of diffusion-weighted imaging (DWI), can non-invasively demonstrate various hemodynamic situations at one time DWI scan with multiple b values. Here, we investigated whether the outcome of BCCAO rats associated with cerebral hemodynamic changes assessed using IVIM- DWI.

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