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Abstract #1782

Directional sensitivity of anomalous diffusion assessed using a tensorial fractional motion model

Boyan Xu1, Gaolang Gong2, Yaoyu Zhang1, Yang Fan3, Bing Wu3, and Jia-Hong Gao1

1Center for MRI Research, Peking University, Beijing, People's Republic of China, 2State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, People's Republic of China, 3MR Research China, GE Healthcare, Beijing, People's Republic of China

Anisotropic diffusion in the nervous system is most commonly modeled by the apparent diffusion tensor, which is based on normal diffusion theory. However, the departure of the diffusion-induced signal attenuation from the mono-exponential form indicates the existence of anomalous diffusion. The fractional motion (FM) model, which is considered as the appropriate anomalous diffusion theory for biological tissues, has been applied to diffusion MRI. However, the directional sensitivity of the FM model in biological tissues remains elusive. In this study, this issue was addressed via tensor analysis in analogy with the diffusion tensor.

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