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Abstract #1806

Rapid Measurement of Perfusion Fraction in Clinical Neuroimaging

Emma M Meeus1,2,3, Jan Novak2,3, Hamid Dehghani1,4, and Andrew C Peet2,3

1Physical Sciences of Imaging in Biomedical Sciences (PSIBS), University of Birmingham, Birmingham, United Kingdom, 2Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom, 3Department of Oncology, Birmingham Children's Hospital, Birmingham, United Kingdom, 4School of Computer Science, University of Birmingham, Birmingham, United Kingdom

This study investigated the reliability of using a rapid three b-value diffusion-weighted imaging to determine intravoxel incoherent motion (IVIM) parameters. Grey matter simulations were conducted to assess the bias and reproducibility of the parameters with b-value distributions: b0,300,500,1000, b0,500,1000 and b0,300,1000. The same b-value distributions were assessed with a volunteer cohort. The results showed that the use of two high b-values provided a good estimate of the perfusion fraction, which was further improved by an increase in the SNR level. In conclusion, the measurement of IVIM-f was achievable using a three b-value protocol.

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