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Abstract #1815

Towards interpretation of 3-tissue constrained spherical deconvolution results in pathology

Thijs Dhollander1, David Raffelt1, and Alan Connelly1,2

1The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 2The Florey Department of Neuroscience, University of Melbourne, Melbourne, Australia

Multi-shell multi-tissue constrained spherical deconvolution (MSMT-CSD) and single-shell 3-tissue CSD (SS3T-CSD) resolve WM fibre orientation distributions and GM and CSF tissue compartments by deconvolving WM, GM and CSF response functions from the diffusion MRI data. We aim for more general interpretation of the “WM/GM/CSF” compartments obtained from 3-tissue CSD methods, specifically in the presence of pathology. We demonstrate their potential in this context and provide a simple framework that aids interpretation, with healthy tissues as a frame of reference. “CSF-like” partial volume is related to interstitial fluid, while “GM-like” partial volume may indicate gliosis, given an appropriate context.

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