Distinguishing bowel regions with fibrosis and regions with active inflammation would be clinically useful in Crohn’s disease to determine best therapy. Commonly used ADC model of DW-MRI, which encapsulates multiple diffusion components into a single parameter, may not suffice to fully describe tissue microenvironments. IVIM model, which describes fast and slow diffusion components, is not commonly used in clinic because of challenges of reliably estimating its parameters due to noise and physiological motion. We recently introduced a motion-compensated spatially-constrained incoherent motion model (MC-SCIM) for reliable parameter estimation. Here we compared MC-SCIM parameters to scores of inflammation and fibrosis from histopathology.