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Abstract #1831

IVIM-derived parameters in evaluating the pathological features and hypoxia of nasopharyngeal carcinoma xenografts

Youping Xiao1, Yunbin Chen1, Xiang Zheng1, Ying Chen1, Li Peng1, Jianji Pan2, and Weibo Chen3

1Radiology, Fujian Medical University Cancer Hospital, Fuzhou, People's Republic of China, 2Radiation Oncology, Fujian Medical University Cancer Hospital, Fuzhou, People's Republic of China, 3Philips Healthcare, Shanghai, People's Republic of China

Intravoxel incoherent motion diffusion weighted imaging was conducted on different radio-sensitive human NPC xenografts (CNE-1 and CNE-2) in order to investigate its application value in assessing the pathological features and tumor’s hypoxia of xenografts. CNE-2 xenografts of higher radio-sensitivity behaved greater changes on IVIM-parameters than CNE-1 xenografts of lower radio-sensitivity after fractional radiations. D and f values correlated significantly with the pathological features and tumor’s hypoxia of xenografts. Thus, IVIM-parameters is potentially valuable in evaluating the effect of radiotherapy in NPC.

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