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Abstract #1837

Towards a practical protocol for accurate and reliable MR-derived diffusion changes of the optic nerve in optic neuritis

Weiling Lee1, Soo Lee Lim1, Ling Ling Chan1, Winston Eng Hoe Lim1, and Helmut Rumpel1

1Diagnostic Radiology, Singapore General Hospital, Singapore, Singapore

Optic neuritis is a demyelinating inflammation of the optic nerve that often occurs in association with multiple sclerosis and neuromyelitis optica. Magnetic resonance imaging (MRI), especially diffusion-tensor imaging (DTI) is highly sensitive for inflammatory changes in the optic nerves. We propose a DTI protocol which balances susceptibility artefacts, scan time, and resolution for better image quality and clinical practicality. It allows a 1 mm in-plane resolution in order to avoid partial volume averaging with cerebrospinal fluid (CSF) surrounding the optic nerve in examining fractional anisotropy (FA) values and apparent diffusion coefficient (ADC) for severity of optic neuritis.

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