Optic neuritis is a demyelinating inflammation of the optic nerve that often occurs in association with multiple sclerosis and neuromyelitis optica. Magnetic resonance imaging (MRI), especially diffusion-tensor imaging (DTI) is highly sensitive for inflammatory changes in the optic nerves. We propose a DTI protocol which balances susceptibility artefacts, scan time, and resolution for better image quality and clinical practicality. It allows a 1 mm in-plane resolution in order to avoid partial volume averaging with cerebrospinal fluid (CSF) surrounding the optic nerve in examining fractional anisotropy (FA) values and apparent diffusion coefficient (ADC) for severity of optic neuritis.
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