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Abstract #1838

Joint estimation of free water and perfusion fraction in human brain

Anna Scherman Rydhög1, André Ahlgren1, Filip Szczepankiewicz1, Ronnie Wirestam1, Carl-Fredrik Westin2, Linda Knutsson1,3, and Ofer Pasternak2

1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 3Department of Radiology (Adjunct), Johns Hopkins School of Medicine, Baltimore, MD, United States

The perfusion of blood affects the estimation of diffusivities, especially fast components such as free water. Here, we acquired human data to demonstrate the applicability of a three-compartment model for the joint estimation of tissue diffusivities, free water, and the perfusion fraction. We evaluated the feasibility of the model by comparing a multiple b-value approach with a shorter, clinically feasible approach. The conclusion is that the two-compartment free-water estimation is affected by both water and blood. The three-compartment model disentangles these effects, useful in distinguishing between changes originating from capillary blood from those originating from the extracellular space.

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