Abstract #1844

Harmonization for DTI measurements mapping across sites in multi-center MRI study

Chuanzhu Sun¹, Lijun Bai¹, Hao Yan^2,3, Shan Wang¹, Xiaocui Wang¹, Xianjun Li^1,4, Chao Jin⁵, Xiaocheng Wei⁶, Hong Yin^7,8, Zengjun Zhang⁹, Xiaoqun Yao¹⁰, Xiaoling Zhang¹¹, Jian Yang⁵, Jian Yang⁵, and Jian Yang⁵

¹Department of Biomedical Engineering, the Key Laboratory of Biomedical Information Engineering of the Ministry of Education, Xi'an Jiaotong University, Xi'an, People's Republic of China, ²Xidian University, Xidian University, People's Republic of China, ³Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen University, shenzhen, People's Republic of China, ⁴Department of Radiology, the First Affiliated Hospital, Xi’an Jiaotong University, xi'an, People's Republic of China, ⁵Department of Radiology, the First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China, ⁶MR Research China, GE Healthcare, Beijing, People's Republic of China, ⁷Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, People's Republic of China, ⁸Department of Radiology, Xijing Hospital, Fourth Military Medical University, xi'an, People's Republic of China, ⁹Department of Diagnostic Radiology, Xi’an Children Hospital, Xi'an, People's Republic of China, ¹⁰Department of Radiology, Xi’an Gao Xin Hospital, Xi'an, People's Republic of China, ¹¹Department of MRI Diagnosis, Shannxi Provincial People’s Hospital, Xi'an, People's Republic of China

Despite the fact that multi-site diffusion imaging studies are increasingly used to study brain disorders, but it is noteworthy that there are large differences among diffusion measurements from different sites. The current study aimed to confirm the variability and to harmonize data across sites. Our results indicated that not only DTI metrics in human brain within inter-site but also within inter-site changed obviously. Furthermore, a brain voxel-based model was developed to harmonize the DTI metrics and to reduce the deviation compared with reference site data and thus improve the reliability of group analysis in multi-center study.

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