Despite the fact that multi-site diffusion imaging studies are increasingly used to study brain disorders, but it is noteworthy that there are large differences among diffusion measurements from different sites. The current study aimed to confirm the variability and to harmonize data across sites. Our results indicated that not only DTI metrics in human brain within inter-site but also within inter-site changed obviously. Furthermore, a brain voxel-based model was developed to harmonize the DTI metrics and to reduce the deviation compared with reference site data and thus improve the reliability of group analysis in multi-center study.
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