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Abstract #1843

Intravoxel Incoherent Motion (IVIM) in Evaluation of Orbital Masses

Ya-wen AO1, Jun Chen 1, Liang Zhang1, Fei Sang1, Hong-yan Nie1, Dong-jie Huang1, Hui Lin2, and Bing Wu2

1Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China, 2GE Healthcare China, Shanghai, People's Republic of China

Diffusion-weighted imaging (DWI) has been proven that malignant orbital masses demonstrate significantly and visually appreciable lower apparent diffusion coefficient (ADC) than benign orbital masses[1-2]. Nevertheless, ADC cannot separate the pure molecular diffusion from the motion of water molecules in the capillary network; thus, perfusion contamination would increase the ADC value. According to the IVIM DWI model[3], both microscopic perfusion and diffusivity can be separated using a biexponential decay function, providing additional parameters for tissue characterization. From the result we can see that it is feasible that quantitative parameters of orbital masses can be derived from IVIM DWI.

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