Abstract #1842

In Vivo 3D Single-Shot Echo-Planar DWI at 7T for Mapping Tissue Microstructure using Mean Apparent Propagator (MAP) MRI

Alexandru Korotcov^1,2, Asamoah Bosomtwi^1,2, Elizabeth Hutchinson^1,3, Michal Komlosh^1,3, Carlo Pierpaoli³, Peter J Basser³, Andrew Hoy^2,4, and Bernard Dardzinski^2,4

¹Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, United States, ²Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD, United States, ³Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States, ⁴Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States

A number of advanced diffusion models have demonstrated great promise for mapping tissue microstructure in ex vivo studies with high resolution and fidelity using a wide range of diffusion weightings, but the increased acquisition time (days) is not feasible in vivo. In this study we have addressed some basic DWI acquisition pitfalls by using 3D single-shot EPI on a high-field (7 Tesla) pre-clinical MRI system, and adapted one of the most promising diffusion modeling techniques, mean apparent propagator (MAP) MRI in vivo to derive information about rat brain microstructure within a reasonable time frame.

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