Meeting Banner
Abstract #1871

Diffusion MRI and magnetic resonance spectroscopy reveal microstructural and functional alteration in chronic mild stress exposed rat brains: A CMS recovery study

Ahmad Raza Khan1, Brian Hansen1, Ove Wiborg2, Christopher D Kroenke3, and Sune N Jespersen1,4

1Clinical Medicine, Center of Functionally Integrative Neuroscience, Aarhus, Denmark, 2Clinical Medicine, Translational Neuropsychiatry Unit, Risskov, Denmark, 3Advanced Imaging Research Center, Portland, OR, United States, 4Department of Physics and Astronomy, Aarhus, Denmark

Chronic mild stress (CMS) exposure leads to depression and other psychiatric disorder. Temporal changes post CMS exposure is still unclear. Present study employed CMS exposure on rats and utilised in-vivo longitudinal diffusion MRI and magnetic resonance spectroscopy (MRS) to reveal microstructural and functional alterations up to eight weeks post CMS exposure. Advanced diffusion kurtosis metrics have revealed significant alteration in stress sensitive regions, such as amygdala, hippocampus, prefrontal cortex and caudate putamen. MRS also showed significant metabolic alteration in ventral hippocampus, particularly on week1 post CMS exposure. Present finding could be useful in treatment of depression or similar disorders.

This abstract and the presentation materials are available to members only; a login is required.

Join Here