The prominent syndrome of HM such as spastic paraparesis is usually considered resulting from abnormal function of thoracic segments, nevertheless, the involvement of intracranial fibers and cervical spinal cord is not clear. In this study, we found a widespread and robust white matter tract abnormality in brain of HM and non-HM patients, without significant difference with cervical spinal cord. Our finding may help shedding light on the underlying pathological mechanism of HM.
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