Abstract #1875

White matter abnormalities of brain and cervical spinal cord in Hepatic Myelopathy patients: a diffusion tensor imaging study

Liu-Xian Wang¹, Lin Liu², Kang Liu³, Ning-Bo Fei⁴, Long-Biao Cui³, Yi-Bin Xi³, Ting-Ting Liu³, Wei Qin², and Hong Yin³

¹Department of Radiology, Xijing Hospital, The Fourth Military Medical University, shaanxi, xi'an, People's Republic of China, ²School of Life Sciences and Technology, Xidian University, People's Republic of China, ³the fourth military medical university, People's Republic of China, ⁴School of Life Sciences and Technology, Xidian University, xi'an, People's Republic of China

The prominent syndrome of HM such as spastic paraparesis is usually considered resulting from abnormal function of thoracic segments, nevertheless, the involvement of intracranial fibers and cervical spinal cord is not clear. In this study, we found a widespread and robust white matter tract abnormality in brain of HM and non-HM patients, without significant difference with cervical spinal cord. Our finding may help shedding light on the underlying pathological mechanism of HM.

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